What Can Actually Go Wrong During a Colonoscopy

July 8, 2026 Off By Miguel Hoffman

Millions of Americans get a colonoscopy every year. For most of them, the whole experience plays out exactly the way the doctor described: a miserable day of prep, a couple of hours of fogginess after the procedure, and a clean report a few weeks later. It’s one of the most effective preventive screenings modern medicine has.

The other side of that picture is the small percentage of cases where something goes wrong. The complications are rare enough that nobody really prepares for them mentally. They’re also serious enough that when they happen, the patient often ends up back in the ER within a day or two.

Why Doctors Push So Hard for Screening

The CDC recommends routine colorectal cancer screening starting at age 45, following a 2021 update from the U.S. Preventive Services Task Force that moved the starting age down from 50. Colonoscopy is the gold standard for one specific reason: it does two things in the same visit. It finds precancerous polyps, and it removes them right then. That combination is the reason colorectal cancer rates have been dropping for two decades.

Skipping the screening has real costs. Colorectal cancer remains one of the most common cancers in the country, and early catch dramatically changes survival.

Where Things Go Sideways

When a colonoscopy goes wrong, the errors generally fall into a handful of categories.

  • Bowel perforation. The scope or biopsy tool punches through the colon wall. This is the most serious of the complications, and it usually means surgery.
  • Anesthesia trouble. Sedation that goes too deep, or insufficient monitoring during the procedure.
  • Polyps or cancers that get missed. The lesion was there but didn’t get seen, or got seen but didn’t get biopsied.
  • Incomplete removal. A polyp gets partially taken out, and the rest sits there and grows.
  • Results that don’t get reported. The gastroenterologist finishes the procedure but the findings never reach the primary care doctor or the patient.

None of these are bizarre. They’re known failure modes. And every one of them is preventable with the right protocol.

Symptoms to Take Seriously After the Procedure

Most patients feel fine within hours. A few things in the day or two after a colonoscopy mean you need to go back in immediately.

  • Sharp abdominal pain that wasn’t there before.
  • Fever over 101.
  • Heavy rectal bleeding, more than light spotting.
  • Persistent vomiting, or not being able to keep fluids down.
  • Fast heart rate, dizziness when you stand up.

Any of those can mean a perforation, a serious infection, or significant bleeding. The window to catch it and contain the damage is short, and patients who get blown off when they call with these symptoms sometimes end up much worse than they should’ve been.

When It Crosses Into Malpractice

A colonoscopy complication isn’t automatically negligence. Even with perfect technique, a small percentage of these procedures will have a bad outcome. The legal question is whether the doctor met the accepted standard of care.

Negligence shows up in specific ways. Rushing the procedure. Skipping documentation. Ignoring a patient who keeps calling with symptoms afterward. Missing or downplaying a perforation that should have been caught in the first hour. The cases where the patient described severe pain for hours before anyone took it seriously, those are a familiar pattern.

When the Records Need a Look

Patients hurt by a colonoscopy complication should ask for the full procedure and post-procedure records as soon as they can. colonoscopy malpractice cases in Maryland get reviewed with gastroenterology experts who can read the technique, the timing, and the follow-up.

Bottom Line

Colonoscopy is safe for the overwhelming majority of patients, and it stays a critical screening tool for catching colorectal cancer early. The rare complications that do occur are well-mapped and often preventable. Patients who develop concerning symptoms in the days after the procedure should be taken seriously, and the records of what happened should be preserved while the trail is still warm.